Processed file: input.fasta
Number of sequences: 9
Alignment assumed to be: Protein
New number of positions: 279 (selected positions are underlined in blue)
10 20 30 40 50 60
=========+=========+=========+=========+=========+=========+
Mouse_Dnmt1 MPARTAPARVPALASPAGSLPDHVRRRLKDLERDGLTEKECVREKLNLLHEFLQTEIKSQ
Human_DNMT1 MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQ
Dog_DNMT1 MPARTAPARVPTLASRALSLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQ
Mouse_Dnmt3a -----MPSSGPGDTSSSSLEREDDRKEGEE------------------------------
Human_DNMT3A MPA--MPSSGPGDTSSSAAEREEDRKDGEE------------------------------
Dog_DNMT3A MPA--MPSSGPGDTSSSAPEREEDRKEGEE------------------------------
Mouse_Dnmt3b --------------------MKGDSRHLNE------------------------------
Human_DNMT3B --------------------MKGDTRHLNG------------------------------
Dog_DNMT3B --------------------MKGDTRQLNR------------------------------
70 80 90 100 110 120
=========+=========+=========+=========+=========+=========+
Mouse_Dnmt1 LCDLETKLHKEELSEEGYLAKVKSLLNKDLSLENGTHTLTQKANGCPANGSRPT---WRA
Human_DNMT1 LCDLETKLRKEELSEEGYLAKVKSLLNKDLSLENGAHAYNREVNGRLENGNQARSEARRV
Dog_DNMT1 LCDLETKLHKEELSEEGYLAKVKSLLNKDLSLENGAHAFSREMNGCLENGSQTSGEDRRV
Mouse_Dnmt3a ----------------------------------------QEENRGKEERQEPSATARKV
Human_DNMT3A ----------------------------------------QEEPRGKEERQEPSTTARKV
Dog_DNMT3A ----------------------------------------QEEARGKEERQEPSTTARKV
Mouse_Dnmt3b ----------------------------------------EEGASGYEECIIVNGNFSDQ
Human_DNMT3B ----------------------------------------EEDAGGREDSILVNGAC---
Dog_DNMT3B ----------------------------------------EEDASGREDSIITNGVCSDQ
130 140 150 160 170 180
=========+=========+=========+=========+=========+=========+
Mouse_Dnmt1 EMADSNRSPRSRPKP------RGPRRSKSDSDTLSVETSPSSVATRRTTRQTTITAHFTK
Human_DNMT1 GMADANSPPKPLSKP------RTPRRSKSDGEAKP-EPSPSPRITRKSTRQTTITSHFAK
Dog_DNMT1 GMAEENKSPKPVSKL------CTPRRSKSDGETKSEASSSSPRITRQTTRQTTILSHFAR
Mouse_Dnmt3a GRPGRKRKHPPVESS------DTP-------KDPAVTTKSQPMAQDSGPSDLLPNGDLEK
Human_DNMT3A GRPGRKRKHPPVESG------DTP-------KDPAVISKSPSMAQDSGASELLPNGDLEK
Dog_DNMT3A GRPGRKRKHPPVESS------DTP-------KDSAVTSKSPSMAQDSGPSELLPNGDLEK
Mouse_Dnmt3b SSDTKDAPSPPVLEAICTEPVCTP-------ETRG--RRSSSRLSKREVSSLLNY-----
Human_DNMT3B --SDQSSDSPPILEAI-----RTP-------EIRG--RRSSSRLSKREVSSLLSY-----
Dog_DNMT3B SSDSKDAPSPPILEAI-----STP-------EIRG--RRSSSRLSKREVSSLLSY-----
190 200 210 220 230 240
=========+=========+=========+=========+=========+=========+
Mouse_Dnmt1 GPTKRKPKEESEEGNSAESAAEER-DQD-KKRRVVDTESGAAA-AVEKLEEVTAGTQLGP
Human_DNMT1 GPAKRKPQEESERAKSDESIKEEDKDQDEKRRRVTSRERVARPLPAEEPERAKSGTRTEK
Dog_DNMT1 GPAKRKPEEEPDKAKSDDSLEEEN-DQEEKRRRVTSREQGARALPAEEPERVQPGTHMDE
Mouse_Dnmt3a RSEPQPEEGSPAAGQKGGAPAEGE---------------GTET-PPEASRAVENGCCVTK
Human_DNMT3A RSEPQPEEGSPAGGQKGGAPAEGE---------------GAAETLPEASRAVENGCCTPK
Dog_DNMT3A RSEPQPEEGSPAGGQKGGAPAEGE---------------GAAETPPEASRAVENGCCTPK
Mouse_Dnmt3b ------TQDMTGDGDRDDEVDDGN---------------GSDI-LMPKLTR---------
Human_DNMT3B ------TQDLTGDGDG----EDGD---------------GSDTPVMPKLFR---------
Dog_DNMT3B ------TQDLTGDGDGEG--EDGD---------------GSDTPVMPKLFR---------
250 260 270 280 290 300
=========+=========+=========+=========+=========+=========+
Mouse_Dnmt1 EEPCEQEDDNRSLRRHTRELSLRRKSKEDPDREARPETHLDEDEDGKKDKRSSRPRSQPR
Human_DNMT1 EEERDEKEEKR-LRSQTKEPTPKQKLKEEPDREARAGVQADEDEDG-DEKDEKKHRSQPK
Dog_DNMT1 EEEREEKEEKR-LRSQTKEPTPKPKSKEEPDREGRTGLQG--EMDG-DEKDEKRPRSQPK
Mouse_Dnmt3a EGRGASAGEGK----EQKQTNIESMKMEGSRGRLRGGL---------GWESSLRQRPMPR
Human_DNMT3A EGRGAPAEAGK----EQKETNIESMKMEGSRGRLRGGL---------GWESSLRQRPMPR
Dog_DNMT3A DGRGAPTEESK----EQKETNIESMKMEGSRGRLRGGL---------GWESSLRQRPMPR
Mouse_Dnmt3b ------------------ETKDTRTRSESPAVRTRHSN---------GTSSLERQRASPR
Human_DNMT3B ---------------------ETRTRSESPAVRTRNNN---------SVSSRERHRPSPR
Dog_DNMT3B ---------------------ETRTRSESPAVRTRNNT---------SASSRERHRPSLR
310 320 330 340 350 360
=========+=========+=========+=========+=========+=========+
Mouse_Dnmt1 DPAAKRRPKEAEPEQVAPETPEDRDEDEREEKRRKTTRKKLESHTVPVQSRSERKAAQSK
Human_DNMT1 DLAAKRRPEEKEPEKVNPQISDEKDEDEKEEKRRKTTPKE----------PTEKKMARAK
Dog_DNMT1 DLAAKRRPEEKEPERVKPQVSEEKDEDEKEEKRRKTTSKE----------PNEKKMARTK
Mouse_Dnmt3a ----------LTFQAGDPYYISKRKRDEWLARWKREAEKK----------------AKVI
Human_DNMT3A ----------LTFQAGDPYYISKRKRDEWLARWKREAEKK----------------AKVI
Dog_DNMT3A ----------LTFQAGDPYYISKRKRDEWLARWKREAEKK----------------AKVI
Mouse_Dnmt3b ----------ITRGRQGRHHVQEYPVEFPATRSRR---RR----------------ASSS
Human_DNMT3B ----------STRGRQGRNHVDESPVEFPATRSLR---RR----------------ATAS
Dog_DNMT3B ----------ATRGRQGRNHVDESPVELSATRSLR---RR----------------TVSL
370 380 390 400 410 420
=========+=========+=========+=========+=========+=========+
Mouse_Dnmt1 SVIP-KINSPKCPECGQHLDDPNLKYQQHPEDAVDEPQMLTSEKLSIYDSTSTWFDTYED
Human_DNMT1 TVMNSKTHPPKCIQCGQYLDDPDLKYGQHPPDAVDEPQMLTNEKLSIFDANESGFESYEA
Dog_DNMT1 TVVSSKTHPLRCVQCGQYLDDAELKYEQHPPDAVDEPQLLTNEKLSIFDANESGFESYEA
Mouse_Dnmt3a AVMN-AVEENQASGESQKVEEAS-------PPAVQQPTDPASPTVAT-TPEPVGGDAGDK
Human_DNMT3A AGMN-AVEENQGPGESQKVEEAS-------PPAVQQPTDPASPTVAT-TPEPVGSDAGDK
Dog_DNMT3A AVMN-AVEENQGSGESQKVEEAS-------PPAVQQPTDPASPTVAT-TPEPVGADAGDK
Mouse_Dnmt3b ASTP-WSSPASV----DFMEEVT-------PKSVSTP----SVDLSQ-DGDQEGMDTTQV
Human_DNMT3B AGTP-WPSPPSSYLTIDLTDDTEDTHGT--PQSSSTP----YARLAQ-DSQQGGMESPQV
Dog_DNMT3B AGTP-WPSPGSPYLTIDLTDDDVV------PQSSSTP----YTRLAQ-DSQQEGLESPQV
############
430 440 450 460 470 480
=========+=========+=========+=========+=========+=========+
Mouse_Dnmt1 SPMHRFTSFSVYCSRGHLCPVDTGLIEKNVELYFSGCAKAIHDENPSMEGGINGKNLGP-
Human_DNMT1 LPQHKLTCFSVYCKHGHLCPIDTGLIEKNIELFFSGSAKPIYDDDPSLEGGVNGKNLGP-
Dog_DNMT1 LPQHKLTCFSVYCKRGHLCPIDTGLIEKNVELFFSGYAKPIYDDDPSLEGGVNGKNLGP-
Mouse_Dnmt3a NATKAADDEPEYEDGRGF-----------------GIGELVW-------GKLRGFSWWPG
Human_DNMT3A NATKAGDDEPEYEDGRGF-----------------GIGELVW-------GKLRGFSWWPG
Dog_DNMT3A NTTKAADDEPEYEDGRGF-----------------GIGELVW-------GKLRGFSWWPG
Mouse_Dnmt3b DAESRDGDSTEYQDDKEF-----------------GIGDLVW-------GKIKGFSWWPA
Human_DNMT3B EADSGDGDSSEYQDGKEF-----------------GIGDLVW-------GKIKGFSWWPA
Dog_DNMT3B DAEGRDADSAEYQDGKEF-----------------GIGDLVW-------GKIKGFSWWPA
############ ##########
490 500 510 520 530 540
=========+=========+=========+=========+=========+=========+
Mouse_Dnmt1 -INQWWLSGFDGGEKVLIGFSTAFAEYILMEPSKEYEPIFGLMQEKIYISKIVVEFLQNN
Human_DNMT1 -INEWWITGFDGGEKALIGFSTSFAEYILMDPSPEYAPIFGLMQEKIYISKIVVEFLQSN
Dog_DNMT1 -INEWWITGFDGGEKALIGFSTSFAEYILMDPNPEYAPLFSVMQEKIYISKIVVEFLQSN
Mouse_Dnmt3a RIVSWWMT---GRSRAAEGTR-----WVM---------WFGDGK----FSVVCVEKL---
Human_DNMT3A RIVSWWMT---GRSRAAEGTR-----WVM---------WFGDGK----FSVVCVEKL---
Dog_DNMT3A RIVSWWMT---GRSRAAEGTR-----WVM---------WFGDGK----FSVVCVEKL---
Mouse_Dnmt3b MVVSWKAT---SKRQAMPGMR-----WVQ---------WFGDGK----FSEISADKL---
Human_DNMT3B MVVSWKAT---SKRQAMSGMR-----WVQ---------WFGDGK----FSEVSADKL---
Dog_DNMT3B MVVSWKAT---SKRQAMSGMR-----WVQ---------WFGDGK----FSEVSADKL---
550 560 570 580 590 600
=========+=========+=========+=========+=========+=========+
Mouse_Dnmt1 PDAVYEDLINKIETTVPPSTINVNRFTEDSLLRHAQFVVSQVESYDEAKDDDETPIFLSP
Human_DNMT1 SDSTYEDLINKIETTVPPSGLNLNRFTEDSLLRHAQFVVEQVESYDEAGDSDEQPIFLTP
Dog_DNMT1 PDSTYEDLINKIETTVPPSVLNLNRFTEDSLLRHAQFVVEQVESYDEAGDSDEQPIFLTP
Mouse_Dnmt3a -----------MPLSSFCSAFHQATYNKQPMYRKAIY-----------------------
Human_DNMT3A -----------MPLSSFCSAFHQATYNKQPMYRKAIY-----------------------
Dog_DNMT3A -----------MPLSSFCSAFHQATYNKQPMYRKAIY-----------------------
Mouse_Dnmt3b -----------VALGLFSQHFNLATFNKLVSYRKAMY-----------------------
Human_DNMT3B -----------VALGLFSQHFNLATFNKLVSYRKAMY-----------------------
Dog_DNMT3B -----------VALGLFSQHFNLATFNKLVSYRKAMY-----------------------
610 620 630 640 650 660
=========+=========+=========+=========+=========+=========+
Mouse_Dnmt1 CMRALIHLAGVSLGQRRAT---RRVMGATKEKDKAPTKATTTKLVYQI----FDTFFSEQ
Human_DNMT1 CMRDLIKLAGVTLGQRRAQARRQTIRHSTREKDRGPTKATTTKLVYQI----FDTFFAEQ
Dog_DNMT1 CMRDLIKLAGVTLGKRRAE-RRQTIGHSAKEKDKGPTKATTTKLVYQI----FDTFFAEQ
Mouse_Dnmt3a ---EVLQVASSRAGKLFP------ACHDSDESDSGKAVEVQNKQMIEWALGGFQPSGPKG
Human_DNMT3A ---EVLQVASSRAGKLFP------VCHDSDESDTAKAVEVQNKPMIEWALGGFQPSGPKG
Dog_DNMT3A ---EVLQVASSRAGKLFP------ACHDSDESDTAKAVEVQNKQMIEWALGGFQPSGPKG
Mouse_Dnmt3b ---HTLEKARVRAGKTFS-------------SSPGESLEDQLKPMLEWAHGGFKPTGIEG
Human_DNMT3B ---HALEKARVRAGKTFP-------------SSPGDSLEDQLKPMLEWAHGGFKPTGIEG
Dog_DNMT3B ---HALEKARVRAGKTFP-------------SNPGDSLEDQLKPMLEWAHGGFKPTGIEG
670 680 690 700 710 720
=========+=========+=========+=========+=========+=========+
Mouse_Dnmt1 IEKYDKEDKENAMKRRRCGVCEVCQQPECGKCKACKDMVKFGGTGRSKQACLKRRCPNLA
Human_DNMT1 IEKDDREDKENAFKRRRCGVCEVCQQPECGKCKACKDMVKFGGSGRSKQACQERRCPNMA
Dog_DNMT1 IEKDDKEDKENAFKRRRCGVCEVCQQPECGQCKACKDMVKFGGSGRSKQACQERRCPNMA
Mouse_Dnmt3a LEP---------------------PEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKS
Human_DNMT3A LEP---------------------PEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKS
Dog_DNMT3A LEP---------------------PEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKS
Mouse_Dnmt3b LKPNKKQPVVNKSKVRRSDSRNLEPRRRENKSRRRTT----NDSAASESPPPKRLKTNSY
Human_DNMT3B LKPNNTQPVVNKSKVRRAGSRKLESRKYENKTRRRTAD---DSATSDYCPAPKRLKTNCY
Dog_DNMT3B LKPNNKQPVVNKSKVRRTGSGNLESRKYENKTRRRTAD---DSTASDYCPPPKRLKTNCY
730 740 750 760 770 780
=========+=========+=========+=========+=========+=========+
Mouse_Dnmt1 VKEADDDEEADDDVSEMPSPKKLHQGKKKKQNKDRISWLGQPMKIEENRTYYQKVSIDEE
Human_DNMT1 MKEADDDEEVDDNIPEMPSPKKMHQGKKKKQNKNRISWVGEAVKTDGKKSYYKKVCIDAE
Dog_DNMT1 MKEADDDEEVDDNIPEVPSPKKMHQGKKKKQNKNRISWVGDAVKTDGKKDYYKKVCIDSE
Mouse_Dnmt3a TTEKPKVKEIIDE-----------------RTRERLVY-----EVRQKCRNIEDICISCG
Human_DNMT3A TAEKPKVKEIIDE-----------------RTRERLVY-----EVRQKCRNIEDICISCG
Dog_DNMT3A TTEKPKVKEIIDE-----------------RTRERLVY-----EVRQKCRNIEDICISCG
Mouse_Dnmt3b -GGKDRGE---DE-----------------ESRERMAS-----EVTNNKGNLEDRCLSCG
Human_DNMT3B NNGKDRGD---ED-----------------QSREQMAS-----DVANNKSSLEDGCLSCG
Dog_DNMT3B NNGKDRGE---ED-----------------QSREQMAL-----DVSNNKSNLEDSCLSCG
790 800 810 820 830 840
=========+=========+=========+=========+=========+=========+
Mouse_Dnmt1 MLEVGDCVSVIPDDSSKPLYLARVTALWEDKNGQMMFHAHWFCAGTDTVLGATSDPLELF
Human_DNMT1 TLEVGDCVSVIPDDSSKPLYLARVTALWEDSSNGQMFHAHWFCAGTDTVLGATSDPLELF
Dog_DNMT1 TLEVGDCVSVIPDDSSKPLYLARVTALWEDGSNGQMFHAHWFCAGTDTVLGATSDPLELF
Mouse_Dnmt3a SLNV------------------------------TLEH-----------------PL--F
Human_DNMT3A SLNV------------------------------TLEH-----------------PL--F
Dog_DNMT3A SLNV------------------------------TLEH-----------------PL--F
Mouse_Dnmt3b KKNP------------------------------VSFH-----------------PL--F
Human_DNMT3B RKNP------------------------------VSFH-----------------PL--F
Dog_DNMT3B RKNP------------------------------VSFH-----------------PL--F
850 860 870 880 890 900
=========+=========+=========+=========+=========+=========+
Mouse_Dnmt1 LVGECENMQLSYIHSKVKVIYKAPSENWAMEGGTDPETTLPGAEDGKTYFFQLWYNQEYA
Human_DNMT1 LVDECEDMQLSYIHSKVKVIYKAPSENWAMEGGMDPESLLEG-DDGKTYFYQLWYDQDYA
Dog_DNMT1 LVDECEDMQLSYIHSKVKVVYKAPSENWALEGGMDPEALITE-DDGKTYFYQLWYDQDYA
Mouse_Dnmt3a IGGMC--------------------------------------QNCKNCFLECAYQYD--
Human_DNMT3A VGGMC--------------------------------------QNCKNCFLECAYQYD--
Dog_DNMT3A VGGMC--------------------------------------QNCKNCFLECAYQYD--
Mouse_Dnmt3b EGGLC--------------------------------------QSCRDRFLELFYMYD--
Human_DNMT3B EGGLC--------------------------------------QTCRDRFLELFYMYD--
Dog_DNMT3B EGGLC--------------------------------------QTCRDRFLELFYMYD--
910 920 930 940 950 960
=========+=========+=========+=========+=========+=========+
Mouse_Dnmt1 RFESPPKTQPTEDNKHKFCLSCIRLAELRQKEMPKVLEQIEEVDGRVYCSSITKNGVVYR
Human_DNMT1 RFESPPKTQPTEDNKFKFCVSCARLAEMRQKEIPRVLEQLEDLDSRVLYYSATKNGILYR
Dog_DNMT1 RFESPPKTQPTEDNKYKFCVSCARLAEMRQKEIPRVLEQLEDLDNRVLYSSATKNGIQYR
Mouse_Dnmt3a -----------DDGYQSYCTICC--------------------GGREVLMCGNNNCCR--
Human_DNMT3A -----------DDGYQSYCTICC--------------------GGREVLMCGNNNCCR--
Dog_DNMT3A -----------DDGYQSYCTICC--------------------GGREVLMCGNNNCCR--
Mouse_Dnmt3b -----------EDGYQSYCTVCC--------------------EGRELLLCSNTSCCR--
Human_DNMT3B -----------DDGYQSYCTVCC--------------------EGRELLLCSNTSCCR--
Dog_DNMT3B -----------DDGYQSYCTVCC--------------------EGRELLLCSNTSCCR--
########## #############
970 980 990 1000 1010 1020
=========+=========+=========+=========+=========+=========+
Mouse_Dnmt1 LGDSVYLPPEAFTFNIKVASPVKRPKKDPVNETLYPEHYRKYSDYIKGSNLDAPEPYRIG
Human_DNMT1 VGDGVYLPPEAFTFNIKLSSPVKRPRKEPVDEDLYPEHYRKYSDYIKGSNLDAPEPYRIG
Dog_DNMT1 VGDGVYLLPEAFTFNIKLSSPVKRPRKEPVDEDLYPEHYRKYSDYIKGSNLDAPEPYRIG
Mouse_Dnmt3a -----CFCVECVDLLVGPGAAQAAIKEDP------------WNCYM--------------
Human_DNMT3A -----CFCVECVDLLVGPGAAQAAIKEDP------------WNCYM--------------
Dog_DNMT3A -----CFCVECVDLLVGPGAAQAAIKEDP------------WNCYM--------------
Mouse_Dnmt3b -----CFCVECLEVLVGAGTAEDAKLQEP------------WSCYM--------------
Human_DNMT3B -----CFCVECLEVLVGTGTAAEAKLQEP------------WSCYM--------------
Dog_DNMT3B -----CFCVECLEVLVGTGTAADAKLQEP------------WSCYM--------------
########################
1030 1040 1050 1060 1070 1080
=========+=========+=========+=========+=========+=========+
Mouse_Dnmt1 RIKEIHCGKK-KGKVNEADIKLRLYKFYRPENTHRSYNGSYHTDINMLYWSDEEAVVNFS
Human_DNMT1 RIKEIFCPKKSNGRPNETDIKIRVNKFYRPENTHKSTPASYHADINLLYWSDEEAVVDFK
Dog_DNMT1 RIKEIFCTKKSNGRPNETDIKIRINKFYRPENTHKSTPASYHADINLLYWSDEEVVVDFK
Mouse_Dnmt3a ------CGHK------------GTYGLLRRR-----------------------------
Human_DNMT3A ------CGHK------------GTYGLLRRR-----------------------------
Dog_DNMT3A ------CGHK------------GTYGLLRRR-----------------------------
Mouse_Dnmt3b ------CLPQ------------RCHGVLRRR-----------------------------
Human_DNMT3B ------CLPQ------------RCHGVLRRR-----------------------------
Dog_DNMT3B ------CLPQ------------RCHGVLRRR-----------------------------
1090 1100 1110 1120 1130 1140
=========+=========+=========+=========+=========+=========+
Mouse_Dnmt1 DVQGRCTVEYGEDLLESIQDYSQGGPDRFYFLEAYNSKTKNFEDPPNHARSPGNKGKGKG
Human_DNMT1 AVQGRCTVEYGEDLPECVQVYSMGGPNRFYFLEAYNAKSKSFEDPPNHARSPGNKGKGKG
Dog_DNMT1 AVQGRCTVEYGEDLPGCLQDFSAGGPDRFYFLEAYNAKNKSFEDPPNHARSPGNKGKGKG
Mouse_Dnmt3a -----------EDWPSRLQMFFANNHDQ------------EFDPPKVYPPVPAEKRK---
Human_DNMT3A -----------EDWPSRLQMFFANNHDQ------------EFDPPKVYPPVPAEKRK---
Dog_DNMT3A -----------DDWPSRLQMFFANNHDQ------------EFDPPKVYPPVPAEKRK---
Mouse_Dnmt3b -----------KDWNMRLQDFFTTDPDL-----------EEFEPPKLYPAIPAAKRR---
Human_DNMT3B -----------KDWNVRLQAFFTSDTGL------------EYEAPKLYPAIPAARRR---
Dog_DNMT3B -----------KDWNVRLQAFFTSDMGL------------EYEAPKLYPAIPAARRR---
##############
1150 1160 1170 1180 1190 1200
=========+=========+=========+=========+=========+=========+
Mouse_Dnmt1 KGKGKGKHQVSEPKEPEAAIKLPKLRTLDVFSGCGGLSEGFHQAGIS-ETLWAIEMWDPA
Human_DNMT1 KGKGKPKSQACEPSEPEIEIKLPKLRTLDVFSGCGGLSEGFHQAGIS-DTLWAIEMWDPA
Dog_DNMT1 KGKGKAKSQTCEPSEPETEIKLPKLRTLDVFSGCGGLSEGFHQAGIS-ETLWAIEMWDPA
Mouse_Dnmt3a -----------------------PIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDS
Human_DNMT3A -----------------------PIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDS
Dog_DNMT3A -----------------------PIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDS
Mouse_Dnmt3b -----------------------PIRVLSLFDGIATGYLVLKELGIKVEKYIASEVCAES
Human_DNMT3B -----------------------PIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEES
Dog_DNMT3B -----------------------PIRVLSLFDGIATGYLVLKELGIKVEKYVASEVCEES
##################### ##########
1210 1220 1230 1240 1250 1260
=========+=========+=========+=========+=========+=========+
Mouse_Dnmt1 AQAFRLNNPGTTVFTEDCNVLLKLVMAGEVTNSLGQRLPQKGDVEMLCGGPPCQGFSGMN
Human_DNMT1 AQAFRLNNPGSTVFTEDCNILLKLVMAGETTNSRGQRLPQKGDVEMLCGGPPCQGFSGMN
Dog_DNMT1 AQAFRLNNPGSTVFTEDCNVLLKLVMAGEATNSRGQKLPQKGDVEMLCGGPPCQGFSGMN
Mouse_Dnmt3a ITVGMVRHQGKIMYVGDVRSVTQ------------KHIQEWGPFDLVIGGSPCNDLSIVN
Human_DNMT3A ITVGMVRHQGKIMYVGDVRSVTQ------------KHIQEWGPFDLVIGGSPCNDLSIVN
Dog_DNMT3A ITVGMVRHQGKIMYVGDVRSVTQ------------KHIQEWGPFDLVIGGSPCNDLSIVN
Mouse_Dnmt3b IAVGTVKHEGQIKYVNDVRKITK------------KNIEEWGPFDLVIGGSPCNDLSNVN
Human_DNMT3B IAVGTVKHEGNIKYVNDVRNITK------------KNIEEWGPFDLVIGGSPCNDLSNVN
Dog_DNMT3B IAVGTVKHEGNIKYVNDVRNITK------------RNIEEWGPFDLVIGGSPCNDLSNVN
################# ###################
1270 1280 1290 1300 1310 1320
=========+=========+=========+=========+=========+=========+
Mouse_Dnmt1 RFNSRTYSKFKNSLVVSFLSYCDYYRPRFFLLENVRNFVSYRRSMVLKLTLRCLVRMGYQ
Human_DNMT1 RFNSRTYSKFKNSLVVSFLSYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQ
Dog_DNMT1 RFNSRTYSKFKNSLVVSFLSYCDYYRPRYFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQ
Mouse_Dnmt3a PARKGLYEG-TGRLFFEFYRLLHDARPK--------------------------------
Human_DNMT3A PARKGLYEG-TGRLFFEFYRLLHDARPK--------------------------------
Dog_DNMT3A PARKGLYEG-TGRLFFEFYRLLHDARPK--------------------------------
Mouse_Dnmt3b PARKGLYEG-TGRLFFEFYHLLNYTRPK--------------------------------
Human_DNMT3B PARKGLYEG-TGRLFFEFYHLLNYSRPK--------------------------------
Dog_DNMT3B PARKGLYEG-TGRLFFEFYHLLNYTRPK--------------------------------
######### #################
1330 1340 1350 1360 1370 1380
=========+=========+=========+=========+=========+=========+
Mouse_Dnmt1 CTFGVLQAGQYGVAQTRRRAIILAAAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSN
Human_DNMT1 CTFGVLQAGQYGVAQTRRRAIILAAAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSN
Dog_DNMT1 CTFGVLQAGQYGVAQTRRRAIILAAAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSN
Mouse_Dnmt3a --------------------------EGDDRPFF---------------------WLFEN
Human_DNMT3A --------------------------EGDDRPFF---------------------WLFEN
Dog_DNMT3A --------------------------EGDDRPFF---------------------WLFEN
Mouse_Dnmt3b --------------------------EGDNRPFF---------------------WMFEN
Human_DNMT3B --------------------------EGDDRPFF---------------------WMFEN
Dog_DNMT3B --------------------------EGDDRPFF---------------------WMFEN
#
1390 1400 1410 1420 1430 1440
=========+=========+=========+=========+=========+=========+
Mouse_Dnmt1 ITRLSSGPFRTITVRDTMSDLPEIQNGASNSEIPYNGEPLSWFQRQLRGSHYQPILRDHI
Human_DNMT1 ITRLSSGPFRTITVRDTMSDLPEVRNGASALEISYNGEPQSWFQRQLRGAQYQPILRDHI
Dog_DNMT1 ITRLSSGPFRTITVRDTMSDLPEVRNGASALEILYNGEPQSWFQRQLRGSQYQPILRDHI
Mouse_Dnmt3a VVAMGVSDKRDIS----------------------------------RFLESNPVMID--
Human_DNMT3A VVAMGVSDKRDIS----------------------------------RFLESNPVMID--
Dog_DNMT3A VVAMGVSDKRDIS----------------------------------RFLESNPVMID--
Mouse_Dnmt3b VVAMKVNDKKDIS----------------------------------RFLACNPVMID--
Human_DNMT3B VVAMKVGDKRDIS----------------------------------RFLECNPVMID--
Dog_DNMT3B VVAMKVGDKRDIS----------------------------------RFLECNPVMID--
############ ###########
1450 1460 1470 1480 1490 1500
=========+=========+=========+=========+=========+=========+
Mouse_Dnmt1 CKDMSPLVAARMRHIPLFPGSDWRDLPNIQVRLGDGVIAHKLQYTFHDVKNGYSSTGALR
Human_DNMT1 CKDMSALVAARMRHIPLAPGSDWRDLPNIEVRLSDGTMARKLRYTHHDRKNGRSSSGALR
Dog_DNMT1 CKDMSALVAARMRHIPLAPGSDWRDLPNIEVRLSDGTMARKLRYTYHDKKNGCSSTGALR
Mouse_Dnmt3a AKEVSA--AHRARYF-------WGNLPG---------MNRPLASTVNDKLELQE------
Human_DNMT3A AKEVSA--AHRARYF-------WGNLPG---------MNRPLASTVNDKLELQE------
Dog_DNMT3A AKEVSA--AHRARYF-------WGNLPG---------MNRPLASTVNDKLELQE------
Mouse_Dnmt3b AIKVSA--AHRARYF-------WGNLPG---------MNRPVMASKNDKLELQD------
Human_DNMT3B AIKVSA--AHRARYF-------WGNLPG---------MNRPVIASKNDKLELQD------
Dog_DNMT3B AIKVSA--AHRARYF-------WGNLPG---------MNRPVIASKNDKLELQD------
###########
1510 1520 1530 1540 1550 1560
=========+=========+=========+=========+=========+=========+
Mouse_Dnmt1 GVCSCAE-GKACDPESRQFSTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPM
Human_DNMT1 GVCSCVEAGKACDPAARQFNTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPM
Dog_DNMT1 GVCSCVEAGKACDSAARQFNTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPM
Mouse_Dnmt3a ----CLEHGRIAK--FSKVRTITTRSNSIKQGKDQHF-------------------PVFM
Human_DNMT3A ----CLEHGRIAK--FSKVRTITTRSNSIKQGKDQHF-------------------PVFM
Dog_DNMT3A ----CLEHGRIAK--FSKVRTITTRSNSIKQGKDQHF-------------------PVFM
Mouse_Dnmt3b ----CLEFSRTAK--LKKVQTITTKSNSIRQGKNQLF-------------------PVVM
Human_DNMT3B ----CLEYNRIAK--LKKVQTITTKSNSIKQGKNQLF-------------------PVVM
Dog_DNMT3B ----CLEFNRTAK--LKKVQTITTKSNSIRQGKNQLF-------------------PVVM
####
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=========+=========+=========+=========+=========+=========+
Mouse_Dnmt1 GKQGRVLHPEQHRVVSVRECARSQGFPDSYRFFGNI--LDRHRQVGNAVPPPLAKAIGLE
Human_DNMT1 GKQGRVLHPEQHRVVSVRECARSQGFPDTYRLFGNI--LDKHRQVGNAVPPPLAKAIGLE
Dog_DNMT1 GKQGRVLHPEQHRVVSVRECARSQGFPDTYRLFGNI--LDKHRQVGNAVPPPLAKAIGLE
Mouse_Dnmt3a NEKEDIL--------WCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAP
Human_DNMT3A NEKEDIL--------WCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAP
Dog_DNMT3A NEKEDIL--------WCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAP
Mouse_Dnmt3b NGKDDVL--------WCTELERIFGFPAHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAP
Human_DNMT3B NGKEDVL--------WCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAP
Dog_DNMT3B NGKEDVL--------WCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAP
####### ##################### ######################
1630 1640
=========+=========+=======
Mouse_Dnmt1 IKLCLLSSARESASAAVKAKEEAATKD
Human_DNMT1 IKLCMLAKARESAS--AKIKEEEAAKD
Dog_DNMT1 IKRCMLAKARESAS--VKTKEEETA--
Mouse_Dnmt3a LKEYFACV-------------------
Human_DNMT3A LKEYFACV-------------------
Dog_DNMT3A LKEYFACV-------------------
Mouse_Dnmt3b LKDYFACE-------------------
Human_DNMT3B LKDYFACE-------------------
Dog_DNMT3B LKDYFACE-------------------
##
Parameters used Minimum Number Of Sequences For A Conserved Position: 5 Minimum Number Of Sequences For A Flanking Position: 8 Maximum Number Of Contiguous Nonconserved Positions: 8 Minimum Length Of A Block: 10 Allowed Gap Positions: None Use Similarity Matrices: Yes
Flank positions of the 16 selected block(s) Flanks: [409 432] [470 479] [913 922] [946 958] [966 989] [1122 1135] [1166 1186] [1191 1217] [1242 1269] [1271 1287] [1380 1392] [1428 1438] [1478 1488] [1557 1567] [1576 1596] [1599 1622] New number of positions in input.fasta-gb: 279 (16% of the original 1647 positions)