M.Dnmt1         MPARTAPARvPalASpAgslpDhvRRRlkDLERDgLTEKECVrEKLNLLHEFLQTEIKsQ
H.DNMT1         MPARTAPARvPtlAvpAislpDDvRRRlkDLERDSLTEKECVKEKLNLLHEFLQTEIKNQ
D.DNMT1         MPARTAPARvPtlASrAlslpDDvRRRlkDLERDSLTEKECVKEKLNLLHEFLQTEIKNQ
M.Dnmt3a        -----mPssGPGdtSSsslerEDDRkegEE------------------------------
H.DNMT3A        MPA--mPssGPGdtSSsaaerEEDRkdgEE------------------------------
D.DNMT3A        MPA--mPssGPGdtSSsaperEEDRkegEE------------------------------
M.Dnmt3b        --------------------mkgDsRhlnE------------------------------
H.DNMT3B        --------------------mkgDtRhlng------------------------------
D.DNMT3B        --------------------mkgDtRQlnr------------------------------

M.Dnmt1         LCDLETKLHKEELSEEGYLAKVKSLLNKDLSLENGtHtltQkanGcpangsrPt---wRa
H.DNMT1         LCDLETKLrKEELSEEGYLAKVKSLLNKDLSLENGAHAYNrEvnGrlEngnqarseaRRV
D.DNMT1         LCDLETKLHKEELSEEGYLAKVKSLLNKDLSLENGAHAFSrEmnGclEngsqtSGedRRV
M.Dnmt3a        ----------------------------------------QEenrGkEErqePSataRKV
H.DNMT3A        ----------------------------------------QEeprGkEErqePSttaRKV
D.DNMT3A        ----------------------------------------QEeArGkEErqePSttaRKV
M.Dnmt3b        ----------------------------------------eEgAsGyEEciivnGnfsdq
H.DNMT3B        ----------------------------------------eEdAGGrEdsilvnGac---
D.DNMT3B        ----------------------------------------eEdAsGrEdsiitnGvcsdq

M.Dnmt1         eMADsnRsprsrpkp------rgPRRSKSDsdtlSVetspSSvAtrRtTrQttitahFtK
H.DNMT1         GMADansppkPlskp------rTPRRSKSDGEakp-epspSpRitrKsTrQttitshFaK
D.DNMT1         GMAEenKspkPVskl------cTPRRSKSDGEtkSeassSSpRitrqtTrQttilshFar
M.Dnmt3a        GrpgRKRKHPPVess------dTP-------kdpAVttKSqpmAQDsgpSdLLpnGDlEK
H.DNMT3A        GrpgRKRKHPPVesg------dTP-------kdpAVisKSpSmAQDsgaSELLpnGDlEK
D.DNMT3A        GrpgRKRKHPPVess------dTP-------kdsAVtsKSpSmAQDsgpSELLpnGDlEK
M.Dnmt3b        ssdtKdapsPPVlEaIctepvcTP-------Etrg--RRSSSRlskRevSsLLny-----
H.DNMT3B        --SDQssdsPPIlEaI-----rTP-------Eirg--RRSSSRlskRevSsLLsy-----
D.DNMT3B        ssdsKdapsPPIlEaI-----sTP-------Eirg--RRSSSRlskRevSsLLsy-----

M.Dnmt1         GPtKrKpkEeseeGnsaesaAEer-DQD-KkRRVvdtEsGAaa-avEKleeVtaGtqlgp
H.DNMT1         GPaKrKpqEeseraksDesikEeDkDQDEKRRRVTSRErvArplPaEepeRakSGtrTeK
D.DNMT1         GPaKrKpEEePdkaksDdsleEen-DQeEKRRRVTSREqGAralPaEepeRVQpGthmde
M.Dnmt3a        rsEpQpEEgsPAaGqKgGApAEGE---------------Gtet-PpEasraVENGCcvtK
H.DNMT3A        rsEpQpEEgsPAgGqKgGApAEGE---------------GAaetlpEasraVENGCcTpK
D.DNMT3A        rsEpQpEEgsPAgGqKgGApAEGE---------------GAaetPpEasraVENGCcTpK
M.Dnmt3b        ------tqDmtgdGDRDdevddGn---------------Gsdi-lmpKltR---------
H.DNMT3B        ------tqDltgdGDg----edGD---------------GsdtpvmpKlfR---------
D.DNMT3B        ------tqDltgdGDgEG--edGD---------------GsdtpvmpKlfR---------

M.Dnmt1         EEpceQeDdnrsLRrhtrElslrRKsKEdPdreaRpethlDEDEDGkkdkrSsRpRsqPR
H.DNMT1         EEerdEkEEkr-LRSqtKEptpKQKlKEePdreaRaGvQaDEDEDG-dekdekkhRsqPk
D.DNMT1         EEereEkEEkr-LRSqtKEptpKpKsKEePdregRtGlQg--emDG-dekdekRpRsqPk
M.Dnmt3a        EgRgAsagEGK----EQKqTNiEsmKmEGsrgRlRgGl---------GwESSlRQRPMPR
H.DNMT3A        EgRgApaEaGK----EQKETNiEsmKmEGsrgRlRgGl---------GwESSlRQRPMPR
D.DNMT3A        dgRgAptEEsK----EQKETNiEsmKmEGsrgRlRgGl---------GwESSlRQRPMPR
M.Dnmt3b        ------------------ETkdtRtRsEsPavRtRhsn---------GtsSleRQRasPR
H.DNMT3B        ---------------------etRtRsEsPavRtRnnn---------svsSreRhRPsPR
D.DNMT3B        ---------------------etRtRsEsPavRtRnnt---------sasSreRhRPslR

M.Dnmt1         DpAAKRRPkEaepEqvaPetpEdRDeDEreekrRkttrKKleshtvpvqsrSErKaAQSk
H.DNMT1         DlAAKRRPEEkepEKvNPqisDEKDeDEkeekrRkttpKe----------PtEKKMARAk
D.DNMT1         DlAAKRRPEEkepERvkPqvsEEKDeDEkeekrRkttsKe----------PNEKKMARTk
M.Dnmt3a        ----------lTfQagDPYYIskRkrDEwlARwKREAEKK----------------AKvi
H.DNMT3A        ----------lTfQagDPYYIskRkrDEwlARwKREAEKK----------------AKvi
D.DNMT3A        ----------lTfQagDPYYIskRkrDEwlARwKREAEKK----------------AKvi
M.Dnmt3b        ----------iTrgRqgrHHVqEypvefpatRsRR---rr----------------AsSs
H.DNMT3B        ----------sTrgRqgrnHVDEspvefpatRslR---rr----------------AtAs
D.DNMT3B        ----------aTrgRqgrnHVDEspvelsatRslR---rr----------------tvSl

M.Dnmt1         svip-kinspkcpecgQhLDDpNlKYqQHPeDAVDEPQmLtSeKLsiyDststwfDtyed
H.DNMT1         tvMNSkthPpkciqcgQyLDDpdlKYgQHPPDAVDEPQmLtNeKLsiFDanesGfeSyea
D.DNMT1         tvvsSkthPlrcvqcgQyLDDaelKYeQHPPDAVDEPQlLtNeKLsiFDanesGfeSyea
M.Dnmt3a        AvMN-avEenQasgesQkveeaS-------PpAVqQPtdpASptvAt-tPEPvGgDagDk
H.DNMT3A        AgMN-avEenQgpgesQkveeaS-------PpAVqQPtdpASptvAt-tPEPvGsDagDk
D.DNMT3A        AvMN-avEenQgsgesQkveeaS-------PpAVqQPtdpASptvAt-tPEPvGaDagDk
M.Dnmt3b        Astp-wssPasv----dfMeevT-------PksVstP----SvdLsq-DgDqeGmDttqv
H.DNMT3B        Agtp-wpsPpssyltidltDDtedthgt--PqssstP----yaRLAq-DsQqgGmeSpqv
D.DNMT3B        Agtp-wpsPgspyltidltDDdvv------PqssstP----ytRLAq-DsQqeGleSpqv

M.Dnmt1         spmHrftsfSvYCsrGhlCPvDTGLIEKNVELyFSGcakaihDenPSmEGgInGknlgP-
H.DNMT1         lpqHkltcfSvYCkhGhlCPIDTGLIEKNiELFFSGsakpiyDDDPSLEGgVnGknlgP-
D.DNMT1         lpqHkltcfSvYCkrGhlCPIDTGLIEKNVELFFSGyakpiyDDDPSLEGgVnGknlgP-
M.Dnmt3a        nATkAadDepEYeDGrgF-----------------GIGELVW-------GKlRGFSWWPg
H.DNMT3A        nATkAgdDepEYeDGrgF-----------------GIGELVW-------GKlRGFSWWPg
D.DNMT3A        ntTkAadDepEYeDGrgF-----------------GIGELVW-------GKlRGFSWWPg
M.Dnmt3b        dAesrdgDsTEYqDdkEF-----------------GIGDLVW-------GKIKGFSWWPA
H.DNMT3B        eAdsgdgDsSEYqDGkEF-----------------GIGDLVW-------GKIKGFSWWPA
D.DNMT3B        dAegrdaDsAEYqDGkEF-----------------GIGDLVW-------GKIKGFSWWPA

M.Dnmt1         -InqWWlsGFDGGEKvliGFsTaFAEyiLMePSkEYePiFGlmqEKIYiSKivVEfLQnN
H.DNMT1         -IneWWiTGFDGGEKAliGFsTSFAEyiLMDPSPEYAPiFGlmqEKIYiSKivVEfLQSN
D.DNMT1         -IneWWiTGFDGGEKAliGFsTSFAEyiLMDPnPEYAPlFsvmqEKIYiSKivVEfLQSN
M.Dnmt3a        rIVSWWmT---GrsrAAeGtR-----WVM---------WFGDGK----FSvVCVEKL---
H.DNMT3A        rIVSWWmT---GrsrAAeGtR-----WVM---------WFGDGK----FSvVCVEKL---
D.DNMT3A        rIVSWWmT---GrsrAAeGtR-----WVM---------WFGDGK----FSvVCVEKL---
M.Dnmt3b        MvVSWkAT---skrqAmpGmR-----WVq---------WFGDGK----FSEisadKL---
H.DNMT3B        MvVSWkAT---skrqAmsGmR-----WVq---------WFGDGK----FSEVsadKL---
D.DNMT3B        MvVSWkAT---skrqAmsGmR-----WVq---------WFGDGK----FSEVsadKL---

M.Dnmt1         PDavYEDLINKIettVppStiNVnrFtedsLlRhAqfVVsQVESYDEAkDdDEtPIFLsP
H.DNMT1         sDSTYEDLINKIettVppSglNLnrFtedsLlRhAqfVVEQVESYDEAGDSDEQPIFLTP
D.DNMT1         PDSTYEDLINKIettVppSvlNLnrFtedsLlRhAqfVVEQVESYDEAGDSDEQPIFLTP
M.Dnmt3a        -----------mpLssFCSaFhqATyNKqpMYRKAIY-----------------------
H.DNMT3A        -----------mpLssFCSaFhqATyNKqpMYRKAIY-----------------------
D.DNMT3A        -----------mpLssFCSaFhqATyNKqpMYRKAIY-----------------------
M.Dnmt3b        -----------VALGLFsqhFNLATFNKlvsYRKAMY-----------------------
H.DNMT3B        -----------VALGLFsqhFNLATFNKlvsYRKAMY-----------------------
D.DNMT3B        -----------VALGLFsqhFNLATFNKlvsYRKAMY-----------------------

M.Dnmt1         CMRaLihlAGVslGqrrat---rrvmgatkEkDkaptKatttKlvyqi----FDtFfsEq
H.DNMT1         CMRDLiklAGVtlGqrraqaRRQTirHstrEkDrGptKatttKlvyqi----FDtFfaEq
D.DNMT1         CMRDLiklAGVtlGKrrae-RRQTigHsakEkDkGptKatttKlvyqi----FDtFfaEq
M.Dnmt3a        ---EVLQvAssRAGKlFP------AcHDSDESDsGKAvEvQnKqMIEWAlGGFqPsGpkG
H.DNMT3A        ---EVLQvAssRAGKlFP------vcHDSDESDtaKAvEvQnKpMIEWAlGGFqPsGpkG
D.DNMT3A        ---EVLQvAssRAGKlFP------AcHDSDESDtaKAvEvQnKqMIEWAlGGFqPsGpkG
M.Dnmt3b        ---htLEKArVRAGKtFs-------------SsPGEslEDQLKpMLEWAHGGFkPtGiEG
H.DNMT3B        ---haLEKArVRAGKtFP-------------SsPGdslEDQLKpMLEWAHGGFkPtGiEG
D.DNMT3B        ---haLEKArVRAGKtFP-------------SnPGdslEDQLKpMLEWAHGGFkPtGiEG

M.Dnmt1         iEkyDKEDKENAmKrRRCGvcEvCqQpEcgKCKAckdmvKFgGtgrSkqaclKRRcPNlA
H.DNMT1         iEkdDrEDKENAfKrRRCGvcEvCqQpEcgKCKAckdmvKFgGsgrSkqacqeRRcPNmA
D.DNMT1         iEkdDKEDKENAfKrRRCGvcEvCqQpEcgqCKAckdmvKFgGsgrSkqacqeRRcPNmA
M.Dnmt3a        LEP---------------------PEEEkNpyKevyTDMwvEpEAAaYAPPPpaKKPrkS
H.DNMT3A        LEP---------------------PEEEkNpyKevyTDMwvEpEAAaYAPPPpaKKPrkS
D.DNMT3A        LEP---------------------PEEEkNpyKevyTDMwvEpEAAaYAPPPpaKKPrkS
M.Dnmt3b        LkPNkKqpvvNkSKvRRsdSrnLePrrreNKsrrrtT----ndsAASeSPPPKRlKtNsy
H.DNMT3B        LkPNntqpvvNkSKvRRaGSrkLesrKyeNKtrrrtaD---DsatSdYcPaPKRlKtNcy
D.DNMT3B        LkPNnKqpvvNkSKvRRtGSgnLesrKyeNKtrrrtaD---DstASdYcPPPKRlKtNcy

M.Dnmt1         vkEaDDdEEaDDdvsEMPSPKKlHQGKKKKQNkdRISWlGqpmkIeenRtyyqkvsIdee
H.DNMT1         mkEaDDdEEVDDnIPEMPSPKKMHQGKKKKQNknRISWVGEAVktdgKKsyykkvCIdae
D.DNMT1         mkEaDDdEEVDDnIPEvPSPKKMHQGKKKKQNknRISWVGDAVktdgKKdyykkvCIdse
M.Dnmt3a        TtEKpkvkEIiDE-----------------rtRERlvY-----EVrqKcrNIEDiCISCG
H.DNMT3A        TaEKpkvkEIiDE-----------------rtRERlvY-----EVrqKcrNIEDiCISCG
D.DNMT3A        TtEKpkvkEIiDE-----------------rtRERlvY-----EVrqKcrNIEDiCISCG
M.Dnmt3b        -ggKDrgE---DE-----------------esRERmAs-----EVtNnKgNLEDrClSCG
H.DNMT3B        nngKDrgd---ed-----------------QsREqmAs-----dVaNnKssLEDgClSCG
D.DNMT3B        nngKDrgE---ed-----------------QsREqmAl-----dVsNnKsNLEDsClSCG

M.Dnmt1         mLeVGDCVSVIPDDSSKPLYLARVTALWEDkngqmMFHAHWFCAGTDTVLGATSDPLELF
H.DNMT1         TLeVGDCVSVIPDDSSKPLYLARVTALWEDsSNGqMFHAHWFCAGTDTVLGATSDPLELF
D.DNMT1         TLeVGDCVSVIPDDSSKPLYLARVTALWEDgSNGqMFHAHWFCAGTDTVLGATSDPLELF
M.Dnmt3a        SLNV------------------------------TLeH-----------------PL--F
H.DNMT3A        SLNV------------------------------TLeH-----------------PL--F
D.DNMT3A        SLNV------------------------------TLeH-----------------PL--F
M.Dnmt3b        kkNp------------------------------vsFH-----------------PL--F
H.DNMT3B        rkNp------------------------------vsFH-----------------PL--F
D.DNMT3B        rkNp------------------------------vsFH-----------------PL--F

M.Dnmt1         lvGECEnMQLSYIHSKVKVIYKAPSENWAMEGGtDPEttLpGaeDgKtyFfqLwYnqeYA
H.DNMT1         lvdECEDMQLSYIHSKVKVIYKAPSENWAMEGGMDPESLLeG-dDgKtyFyqLwYdqDYA
D.DNMT1         lvdECEDMQLSYIHSKVKVvYKAPSENWAlEGGMDPEALite-dDgKtyFyqLwYdqDYA
M.Dnmt3a        iGGmC--------------------------------------QnCKncFLEcAYqYD--
H.DNMT3A        vGGmC--------------------------------------QnCKncFLEcAYqYD--
D.DNMT3A        vGGmC--------------------------------------QnCKncFLEcAYqYD--
M.Dnmt3b        eGGlC--------------------------------------QsCrDrFLELfYMYD--
H.DNMT3B        eGGlC--------------------------------------QtCrDrFLELfYMYD--
D.DNMT3B        eGGlC--------------------------------------QtCrDrFLELfYMYD--

M.Dnmt1         RFESPPKTQPTeDnkhkfClsCiRLAElRQKEmPkVLEQiEevDGRvycssitKNgvvYR
H.DNMT1         RFESPPKTQPTeDnkfkfCvsCaRLAEMRQKEIPRVLEQLEDLDsRvLyysatKNgilYR
D.DNMT1         RFESPPKTQPTeDnkykfCvsCaRLAEMRQKEIPRVLEQLEDLDnRvLyssatKNgiqYR
M.Dnmt3a        -----------DDGYQSYCTICC--------------------gGREvLMCGNnNCCR--
H.DNMT3A        -----------DDGYQSYCTICC--------------------gGREvLMCGNnNCCR--
D.DNMT3A        -----------DDGYQSYCTICC--------------------gGREvLMCGNnNCCR--
M.Dnmt3b        -----------eDGYQSYCTVCC--------------------EGRELLLCsNtsCCR--
H.DNMT3B        -----------DDGYQSYCTVCC--------------------EGRELLLCsNtsCCR--
D.DNMT3B        -----------DDGYQSYCTVCC--------------------EGRELLLCsNtsCCR--

M.Dnmt1         lGDsVylppEaFtFnikvaspvkrpKkdPVnEtLYPEHYRKySdYiKGSNLDAPEPYRIG
H.DNMT1         VGDGVylppEaFtFniklsspvkrpRkEPVDEDLYPEHYRKySdYiKGSNLDAPEPYRIG
D.DNMT1         VGDGVyllpEaFtFniklsspvkrpRkEPVDEDLYPEHYRKySdYiKGSNLDAPEPYRIG
M.Dnmt3a        -----CFCVECvDlLVGpGAAqAAiKEdP------------WnCYM--------------
H.DNMT3A        -----CFCVECvDlLVGpGAAqAAiKEdP------------WnCYM--------------
D.DNMT3A        -----CFCVECvDlLVGpGAAqAAiKEdP------------WnCYM--------------
M.Dnmt3b        -----CFCVEClEvLVGaGtAedAklqEP------------WSCYM--------------
H.DNMT3B        -----CFCVEClEvLVGtGtAaeAklqEP------------WSCYM--------------
D.DNMT3B        -----CFCVEClEvLVGtGtAadAklqEP------------WSCYM--------------

M.Dnmt1         RIKEIhCgkK-kGkvNEaDIKlRlYkFyRpeNTHrSyngSYHtDINmLYWSDEEAVVnFs
H.DNMT1         RIKEIFCpkKSNGRPNETDIKIRvnkFyRpeNTHKSTPASYHADINLLYWSDEEAVVDFK
D.DNMT1         RIKEIFCtkKSNGRPNETDIKIRinkFyRpeNTHKSTPASYHADINLLYWSDEEvVVDFK
M.Dnmt3a        ------CgHK------------gtYGlLRRR-----------------------------
H.DNMT3A        ------CgHK------------gtYGlLRRR-----------------------------
D.DNMT3A        ------CgHK------------gtYGlLRRR-----------------------------
M.Dnmt3b        ------Clpq------------RChGvLRRR-----------------------------
H.DNMT3B        ------Clpq------------RChGvLRRR-----------------------------
D.DNMT3B        ------Clpq------------RChGvLRRR-----------------------------

M.Dnmt1         dVQGRCTVEYGEDllesiQdysqGgPDrFYFLEAYNsKtKnFEdPpnharsPgnKgKGKG
H.DNMT1         aVQGRCTVEYGEDlPecvQvysmGgPnrFYFLEAYNAKSKsFEdPpnharsPgnKgKGKG
D.DNMT1         aVQGRCTVEYGEDlPgcLQdFsAGgPDrFYFLEAYNAKNKsFEdPpnharsPgnKgKGKG
M.Dnmt3a        -----------EDWPsRLQmFFAnnhDq------------EFdPPKvYPpVPAeKRK---
H.DNMT3A        -----------EDWPsRLQmFFAnnhDq------------EFdPPKvYPpVPAeKRK---
D.DNMT3A        -----------dDWPsRLQmFFAnnhDq------------EFdPPKvYPpVPAeKRK---
M.Dnmt3b        -----------kDWnmRLQdFFttDPDL-----------eEFEPPKlYPAIPAAKRr---
H.DNMT3B        -----------kDWnvRLQaFFtsDtgL------------EyEaPKlYPAIPAArRr---
D.DNMT3B        -----------kDWnvRLQaFFtsDmgL------------EyEaPKlYPAIPAArRr---

M.Dnmt1         KGKGKgKhQvsEPkEPEaaIKLPklRtLdvFsGcgglsegfhqaGIs-etlwAiEmwdpa
H.DNMT1         KGKGKpKSQaCEPSEPEiEIKLPklRtLdvFsGcgglsegfhqaGIs-DtlwAiEmwdpa
D.DNMT1         KGKGKaKSQtCEPSEPEtEIKLPklRtLdvFsGcgglsegfhqaGIs-etlwAiEmwdpa
M.Dnmt3a        -----------------------PIRVLSLFDGIATGlLVLKDLGIqVDRYIASEVCEDS
H.DNMT3A        -----------------------PIRVLSLFDGIATGlLVLKDLGIqVDRYIASEVCEDS
D.DNMT3A        -----------------------PIRVLSLFDGIATGlLVLKDLGIqVDRYIASEVCEDS
M.Dnmt3b        -----------------------PIRVLSLFDGIATGyLVLKeLGIKVeKYIASEVCaES
H.DNMT3B        -----------------------PIRVLSLFDGIATGyLVLKeLGIKVgKYVASEVCEES
D.DNMT3B        -----------------------PIRVLSLFDGIATGyLVLKeLGIKVeKYVASEVCEES

M.Dnmt1         aqafrlnnpGttvftEDcnvllKLVMAGEvTNSlGqrlpqkGdvemlcGGpPCqgfSgmN
H.DNMT1         aqafrlnnpGstvftEDcnillKLVMAGEtTNSRGqrlpqkGdvemlcGGpPCqgfSgmN
D.DNMT1         aqafrlnnpGstvftEDcnvllKLVMAGEaTNSRGqklpqkGdvemlcGGpPCqgfSgmN
M.Dnmt3a        ItVGMVRHQGKImYVgDVRsVTq------------KHIQEWGPFDLVIGGSPCNDLSiVN
H.DNMT3A        ItVGMVRHQGKImYVgDVRsVTq------------KHIQEWGPFDLVIGGSPCNDLSiVN
D.DNMT3A        ItVGMVRHQGKImYVgDVRsVTq------------KHIQEWGPFDLVIGGSPCNDLSiVN
M.Dnmt3b        IAVGtVKHEGQIKYVnDVRkITK------------KnIEEWGPFDLVIGGSPCNDLSnVN
H.DNMT3B        IAVGtVKHEGnIKYVnDVRnITK------------KnIEEWGPFDLVIGGSPCNDLSnVN
D.DNMT3B        IAVGtVKHEGnIKYVnDVRnITK------------rnIEEWGPFDLVIGGSPCNDLSnVN

M.Dnmt1         rfnsrtYskFknsLvvsFlsycDYyRPrFFLLENVRNFVSyrRSMVLKLTLRCLVRMGYQ
H.DNMT1         rfnsrtYskFknsLvvsFlsycDYyRPrFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQ
D.DNMT1         rfnsrtYskFknsLvvsFlsycDYyRPryFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQ
M.Dnmt3a        PARKGLYEG-TGRLFFEFYrLLhdaRPK--------------------------------
H.DNMT3A        PARKGLYEG-TGRLFFEFYrLLhdaRPK--------------------------------
D.DNMT3A        PARKGLYEG-TGRLFFEFYrLLhdaRPK--------------------------------
M.Dnmt3b        PARKGLYEG-TGRLFFEFYHLLnYtRPK--------------------------------
H.DNMT3B        PARKGLYEG-TGRLFFEFYHLLnYsRPK--------------------------------
D.DNMT3B        PARKGLYEG-TGRLFFEFYHLLnYtRPK--------------------------------

M.Dnmt1         CTFGVLQAGQYGVAQTRRRAIILAAApGeklPlFPEPLHVFAPRACQLSVVVDDKkFvsN
H.DNMT1         CTFGVLQAGQYGVAQTRRRAIILAAApGeklPlFPEPLHVFAPRACQLSVVVDDKkFvsN
D.DNMT1         CTFGVLQAGQYGVAQTRRRAIILAAApGeklPlFPEPLHVFAPRACQLSVVVDDKkFvsN
M.Dnmt3a        --------------------------EGDDRPFF---------------------WlFEN
H.DNMT3A        --------------------------EGDDRPFF---------------------WlFEN
D.DNMT3A        --------------------------EGDDRPFF---------------------WlFEN
M.Dnmt3b        --------------------------EGDnRPFF---------------------WmFEN
H.DNMT3B        --------------------------EGDDRPFF---------------------WmFEN
D.DNMT3B        --------------------------EGDDRPFF---------------------WmFEN

M.Dnmt1         itrlssGpfRtItVRDTMSDLPEiqNGASnsEIpYNGEPlSWFQRQLRgshyqPilrDHI
H.DNMT1         itrlssGpfRtItVRDTMSDLPEVRNGASalEIsYNGEPQSWFQRQLRgaQyqPilrDHI
D.DNMT1         itrlssGpfRtItVRDTMSDLPEVRNGASalEIlYNGEPQSWFQRQLRgsQyqPilrDHI
M.Dnmt3a        VVAMGVsDKRDIS----------------------------------RFLEsNPVMID--
H.DNMT3A        VVAMGVsDKRDIS----------------------------------RFLEsNPVMID--
D.DNMT3A        VVAMGVsDKRDIS----------------------------------RFLEsNPVMID--
M.Dnmt3b        VVAMkVnDKkDIS----------------------------------RFLaCNPVMID--
H.DNMT3B        VVAMkVGDKRDIS----------------------------------RFLECNPVMID--
D.DNMT3B        VVAMkVGDKRDIS----------------------------------RFLECNPVMID--

M.Dnmt1         cKDmSpLVAaRmRhiPLfPGSDWrdLPnIqVRLgDGviahkLqyTfhDvkngysSTGALR
H.DNMT1         cKDmSALVAaRmRhiPLaPGSDWrdLPnIEVRLSDGTMaRkLryThhDrkngrsSsGALR
D.DNMT1         cKDmSALVAaRmRhiPLaPGSDWrdLPnIEVRLSDGTMaRkLryTyhDKkngcsSTGALR
M.Dnmt3a        AKEVSA--AHRARYF-------WGNLPG---------MNRPLaSTvNDKLElQE------
H.DNMT3A        AKEVSA--AHRARYF-------WGNLPG---------MNRPLaSTvNDKLElQE------
D.DNMT3A        AKEVSA--AHRARYF-------WGNLPG---------MNRPLaSTvNDKLElQE------
M.Dnmt3b        AikVSA--AHRARYF-------WGNLPG---------MNRPvmAskNDKLElQD------
H.DNMT3B        AikVSA--AHRARYF-------WGNLPG---------MNRPviAskNDKLElQD------
D.DNMT3B        AikVSA--AHRARYF-------WGNLPG---------MNRPviAskNDKLElQD------

M.Dnmt1         GVCSCaE-GkacdPesRqfsTlipwclphtgnrhnHwAGLYGRLEWDGFFSTTVTNPepM
H.DNMT1         GVCSCvEaGkacdPAaRqfnTlipwclphtgnrhnHwAGLYGRLEWDGFFSTTVTNPepM
D.DNMT1         GVCSCvEaGkacdsAaRqfnTlipwclphtgnrhnHwAGLYGRLEWDGFFSTTVTNPepM
M.Dnmt3a        ----CLEHGRIAK--fsKVrTITTRSNSIKQGKDQHF-------------------PVfM
H.DNMT3A        ----CLEHGRIAK--fsKVrTITTRSNSIKQGKDQHF-------------------PVfM
D.DNMT3A        ----CLEHGRIAK--fsKVrTITTRSNSIKQGKDQHF-------------------PVfM
M.Dnmt3b        ----CLEfsRtAK--lKKVQTITTKSNSIRQGKnQlF-------------------PVvM
H.DNMT3B        ----CLEYnRIAK--lKKVQTITTKSNSIKQGKnQlF-------------------PVvM
D.DNMT3B        ----CLEfnRtAK--lKKVQTITTKSNSIRQGKnQlF-------------------PVvM

M.Dnmt1         gKqgrVLHPEQHRVVsvrECaRsqGFPdsYrffgNi--ldRhRqvGnavppPlakaigle
H.DNMT1         gKqgrVLHPEQHRVVsvrECaRsqGFPdtYrlfgNi--ldkhRqvGnavppPlakaigle
D.DNMT1         gKqgrVLHPEQHRVVsvrECaRsqGFPdtYrlfgNi--ldkhRqvGnavppPlakaigle
M.Dnmt3a        NEKEDiL--------WCTEmERVFGFPvHYTDVSNMsRlARQRLLGRSWSVPVIRHLFAP
H.DNMT3A        NEKEDiL--------WCTEmERVFGFPvHYTDVSNMsRlARQRLLGRSWSVPVIRHLFAP
D.DNMT3A        NEKEDiL--------WCTEmERVFGFPvHYTDVSNMsRlARQRLLGRSWSVPVIRHLFAP
M.Dnmt3b        NgKDDVL--------WCTElERIFGFPaHYTDVSNMGRgARQkLLGRSWSVPVIRHLFAP
H.DNMT3B        NgKEDVL--------WCTElERIFGFPvHYTDVSNMGRgARQkLLGRSWSVPVIRHLFAP
D.DNMT3B        NgKEDVL--------WCTElERIFGFPvHYTDVSNMGRgARQkLLGRSWSVPVIRHLFAP

M.Dnmt1         iKlcllssARESASaaVKaKEEaAtKD
H.DNMT1         iKlcmlakARESAS--aKiKEEEAAKD
D.DNMT1         iKrcmlakARESAS--VKtKEEEtA--
M.Dnmt3a        LKeYFACv-------------------
H.DNMT3A        LKeYFACv-------------------
D.DNMT3A        LKeYFACv-------------------
M.Dnmt3b        LKdYFACe-------------------
H.DNMT3B        LKdYFACe-------------------
D.DNMT3B        LKdYFACe-------------------